Name:
Other Names:
CAS No:
Grade:
Product Identity
High-Substituted Hydroxypropyl Cellulose (HPC)
H-HPC
9004-64-2
USP45/CP2020
Product Description
High-Substituted Hydroxypropyl Cellulose (HPC) is a nonionic, water-soluble cellulose derivative widely used in pharmaceuticals, cosmetics, and food industries. Derived from natural cellulose, HPC is modified by introducing hydroxypropyl groups, resulting in enhanced solubility, thermal stability, and film-forming properties. Its high substitution level provides excellent binding, thickening, and stabilizing characteristics, making it a versatile ingredient in tablet formulations, sustained-release drug delivery systems, and as a protective colloid in various applications. Furthermore, HPC’s biocompatibility and inert nature contribute to its popularity in formulations requiring safety and efficacy.
Chemical/ Physical Analysis
| Test Items | Specifications |
| APPEARANCE | White or off-white powder/granules |
| HYDROXYPROPYL CONTENT | 60%-77% |
| Loss on drying | 5% max |
| Residue on ignition | 0.5% max |
| PH value (25° C) | 5-8 |
| Heavy Metal | 20 ppm max |
| Lead | 10 ppm max |
| Chlorides | 0.5% max |
| Particle size | 60 mesh (100% pass) |
Applications
1. Pharmaceutical Industry
- Tablet Binder and Filler: HPC is used as a binder in direct compression and wet granulation for tablet manufacturing.
- Film Coating: It provides a protective coating for tablets and capsules, improving stability and controlling drug release.
- Sustained-Release Systems: HPC aids in controlled drug delivery by forming gels that regulate drug dissolution.
- Stabilizer: It stabilizes suspensions and emulsions in liquid formulations.
2. Food Industry
- Thickening Agent: HPC is used to enhance viscosity in sauces, dressings, and other food products.
- Stabilizer: It prevents phase separation in emulsified systems like whipped toppings and dairy products.
- Dietary Fiber: As a cellulose derivative, HPC can contribute to fiber content in functional foods.
3. Cosmetic and Personal Care Industry
- Film-Former: HPC creates a thin, durable film on the skin or hair, making it ideal for products like lotions, creams, and hair sprays.
- Thickener and Stabilizer: It improves the texture and consistency of formulations, including creams, gels, and emulsions.
4. Industrial Applications
- Adhesives and Coatings: HPC is used in specialty adhesives and coatings for its excellent film-forming and binding capabilities.
- Paper and Textile Industry: It serves as a coating or sizing agent, enhancing durability and finish.
5. Other Applications
- 3D Printing: HPC is explored as a binder and matrix material in 3D printing technologies.
- Biomedical Uses: It is used in hydrogels, wound dressings, and as a scaffold material in tissue engineering.
Packaging
25KG/barrel; or customized packing.
Storage &Transportation Guidelines
Store it in a tightly sealed container to prevent exposure to humidity, avoid extreme heat or freezing temperatures,Protect from direct sunlight, as UV radiation. Transport at ambient temperatures, avoiding extreme conditions