Hydroxypropyl methylcellulose (HPMC) E5

Hydroxypropyl methylcellulose (HPMC) 2910 E5, also known as Hypromellose, is a semi-synthetic cellulose ether and viscoelastic polymer. It is derived from cellulose, a natural substance found in cotton and wood, and is widely used across various industries due to its unique properties.

Key Characteristics of HPMC 2910 E5:

• Solubility: HPMC 2910 E5 is soluble in a range of solvents, including water, organic solvents, and water-organic solvent mixtures.
• Thermal Stability: Unlike some polymers, HPMC does not gel when heated, maintaining its functional properties under a variety of temperature conditions.
• Non-Toxicity: HPMC is non-toxic to humans, making it a safe choice for applications involving direct human contact.

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Raw Material Preparation (Crush the cotton into fine powder)
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Etherification (Combine Methyl Chloride with Propylene Oxide to complete the etherification reaction)
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Neutralization After etherification, the reaction mixture is neutralized, often with an acid, to stop the reaction and remove excess alkali
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Precipitation-The HPMC is then precipitated from the solution using alcohol (usually isopropyl alcohol or ethanol).
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Washing (to remove impurities and residual solvents)
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Drying (moisture control)
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Milling and Sieving (achieve the desired particle size for its intended application.)
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Quality Control
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Packaging
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End

1. Binder in Tablets: It is commonly used as a binder in tablet formulations, helping to hold the ingredients together and ensuring uniformity in tablet weight and strength.
2. Controlled Release: HPMC E5 is employed in controlled-release formulations, allowing for a gradual release of active pharmaceutical ingredients (APIs) over time, which can improve therapeutic efficacy and patient compliance.
3. Thickening Agent: In liquid formulations, such as suspensions and gels, HPMC E5 acts as a thickening agent, improving viscosity and stability.
4. Film Coating: It can be used for film coating of tablets, providing a protective layer that can improve stability, mask taste, and enhance appearance.
5. Stabilizer in Emulsions: HPMC E5 serves as a stabilizer in emulsions, helping to maintain the dispersion of ingredients in topical formulations.
6. Matrix Formulation: In extended-release tablets, it forms a gel matrix that controls the release of drugs, allowing for sustained therapeutic effects.
7. Excipient for Hydrophilic Drugs: It is often used as an excipient for hydrophilic drugs, helping to improve solubility and bioavailability.

HPMC is available in 25kg fiber drums, 20KG cartons, Poly lined with pallets.